- Original Article
- Neonatology (Perinatology)
- Experience and pharmacokinetics of Levetiracetam in Korean neonates with neonatal seizures
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Jae Won Shin, Yun Seob Jung, Kyungsoo Park, Soon Min Lee, Ho Seon Eun, Min Soo Park, Kook In Park, Ran Namgung
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Clin Exp Pediatr. 2017;60(2):50-54. Published online February 27, 2017
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Purpose The aims of this study were to evaluate the safety and pharmacokinetics of levetiracetam (LEV) in neonates with seizures and to establish a population pharmacokinetics (PPK) model by using the software NONMEM. MethodsA retrospective analysis of 18 neonatal patients with seizures, who were treated with LEV, including 151 serum samples, was performed. The mean loading dose was 20 mg/kg, followed by... |
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